Polynucleotides, 8. Base stacking in polyuridylic acid.
نویسندگان
چکیده
منابع مشابه
A proton magnetic resonance study of the interaction of adenosine with polyuridylic Acid: evidence for both adenine-uracil base-stacking and base-pairing.
We report here a proton magnetic resonance (pmr) study of the interaction of adenosine with polyuridylic acid in aqueous solution. The results of this study indicate that the mode of interaction is adenosine intercalation and adenine-uracil base-stacking above 260C, and verifies that a triple-stranded complex which is stabilized by both adenine-uracil hydrogen-bonding and adenineadenine base-st...
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The effect of polyadenylic acid: polyuridylic acid complex (poly A: U) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant or in saline. Addition of 300 ,ug of poly A:U to vaccines rendered 3 X 108 B. melitensis cells in saline as immunogenic as 3 X 10"1 cells in oil adjuvant against a severe B. abortus challenge. In the mouse...
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Estimates have been made of the main contributions of the heterocyclic bases of DNA to the free energies of the two configurations in solution, the two-stranded helix and the single-strand random coil. The magnitude and directions of the dipole moments of the adenine, thymine, guanine and cytosine base groups have been calculated by a semi-empirical molecular orbital treatment. Dipole-dipole, d...
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These equations are plotted in Figure 2, with L as the abscissa. It is evident that for Case I, C7 is independent of L and varies as the square of At, while for the extreme Case II, or large At/T, C7 becomes nearly proportional to L. These relationships are the same as those proposed by Commoner et al. from a more qualitative analysis of the model. In the previous paper, Commoner et al. demonst...
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The association and dissociation rate constants (k(a) and k(d)) of DNA hybridizations involving dual, single or no stacking with different base-pairing sizes were measured, which reveals the advantage of stacking hybridization in both the kinetic and steady state.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1966
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.56.5.1528